We all cope with anxiety and stress, to one degree or another, with the help of a cocktail of chemicals produced in the body and released in the brain. Chief among them is the endorphin group. The endorphins are peptide neurotransmitters that have pain-relieving properties. Anxiety and stress and pain bring on the endorphin response as a natural coping mechanism. When we take any of the opiates-morphine or opium or heroin, in particular-the body stops producing endorphins. When we stop taking opiates, there’s a lag of between five and fourteen days before the body begins a new endorphin production cycle. In the meanwhile, in that black, tortured crawlspace of one to two weeks without heroin and without endorphins, we learn what anxiety and stress and pain really are.

What’s it like, Karla asked me once, cold turkey off heroin? I tried to explain it. Think about every time in your life that you’ve ever been afraid, really afraid. Someone sneaks up behind you when you think you’re alone, and shouts to frighten you. The gang of thugs closes in around you. You fall from a great height in a dream, or you stand on the very edge of a steep cliff. Someone holds you under water and you feel the breath gone, and you scramble, fight, and claw your way to the surface. You lose control of the car and see the wall rushing into your soundless shout. Then add them all up, all those chest-tightening terrors, and feel them all at once, all at the same time, hour after hour, and day after day. And think of every pain you’ve ever known-the burn with hot oil, the sharp sliver of glass, the broken bone, the gravel rash when you fell on the rough road in winter, the headache and the earache and the toothache. Then add them all up, all those groin-squeezing, stomach-tensing shrieks of pain, and feel them all at once, hour after hour, and day after day. Then think of every anguish you’ve ever known. Remember the death of a loved one. Remember a lover’s rejection. Recall your feelings of failure and shame and unspeakably bitter remorse. And add them all up, all the heart-stabbing griefs and miseries, and feel them all at once, hour after hour, and day after day. That’s cold turkey. Cold turkey off heroin is life with the skin torn away.

The assault of anxiety on the unprotected mind, the brain without natural endorphins, makes men and women mad. Every junkie going through turkey is mad. The madness is so fierce and cruel that some die of it. And in the temporary insanity of that skinned, excruciated world, we commit crimes. And if we survive, years later, and become well, our healthy recollection of those crimes leaves us wretched, bewildered, and as self-disgusted as men and women who betray their comrades and country under torture.

Two full days and nights into the torment, I knew I wasn’t going to make it. Most of the vomiting and the diarrhoea had passed, but the pain and anxieties were worse, much worse, every minute. Beneath the screaming in my blood there was a calm, insistent voice: You can stop this… you can fix this… you can stop this… take the money… get a fix… you can stop this pain

Nazeer’s bamboo and coconut-fibre cot was in the far corner of the room. I lurched toward it, watched closely by the burly Afghan, who was still sitting on his mat near the door. Trembling and moaning with pain, I dragged the cot closer to the great window that looked out on the sea. I took up a cotton sheet and began to tear at it with my teeth. It gave way in a few places, and I ripped it along the length, tearing off strips of cloth. Frantic in my movements and close to panic, I hurled two thick, embroidered quilts onto the rope bed for a mattress, and lay down on it. Using two of the strips, I tied my ankles to the bed. With a third strip, I secured my left wrist. Then I lay down, and turned my head to look at Nazeer. I held out the remaining strip, and asked him with my eyes to bind my arm to the bed. It was the first time that we’d ever met one another’s eyes in an equally honest stare.

He rose from his square of carpet and walked toward me, holding the stare. He took the strip of cloth from my hand and bound my right wrist to the frame of the bed. A shout of trapped, panic-fear escaped from my open mouth, and another. I bit down on my tongue, biting through the flesh at the sides until blood ran past my lips. Nazeer nodded slowly. He tore another thick strip from the sheet and twirled it into a corkscrew tube. Sliding it between my teeth, he tied the gag behind my head. And I bit down on the devil’s tail. And I screamed. And I turned my head to see my own reflection tied to the night in the window. And for a while I was Modena, waiting and watching and screaming with my eyes.

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